《Multicenter study of combination DEP regimen as a salvage therapy for adult refractory hemophagocytic lymphohistiocytosis》解读-难治性噬血细胞综合征挽救治疗的临床探索. Recommendations for the management of hemophagocytic lymphohistiocytosis in adults. HLH study Group of the Histiocyte Society. HLH-94: a treatment protocol for hemophagocytic lymphohistiocytosis. The role of chemokines in Hodgkin's disease. IP-10/CXCL10 and MIG/CXCL9 as novel markers for the diagnosis of lymphoma-associated hemophagocytic syndrome. An improved index for diagnosis and mortality prediction in malignancy-associated hemophagocytic lymphohistiocytosis. Zoref-Lorenz A, Murakami J, Hofstetter L, et al. Lymphoma-associated hemophagocytic syndrome in Japan. Development and validation of the HScore, a score for the diagnosis of reactive hemophagocytic syndrome. ![]() HLH-2004: Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis. Haemophagocytic lymphohistiocytosis in patients treated with immune checkpoint inhibitors: analysis of WHO global database of individual case safety reports. Characterization of HLH-like manifestations as a CRS variant in patients receiving CD22 CAR T cells. Lichtenstein DA, Schischlik F, Shao L, et al. Malignancy-associated haemophagocytic lymphohistiocytosis. Setiadi A, Zoref-Lorenz A, Lee CY, et al. Ramos-Casals M, Brito-Zerón P, López-Guillermo A, et al. malignancy-associated hemophagocytic lymphohistiocytosis /.With emerging drugs and ongoing clinical trials, it's worth believing that the diagnosis and management of M-HLH will be optimized, which will ultimately improve prognosis. However, there is still no consensus on the diagnostic criteria and treatment strategies due to lack of large-scale prospective studies. In recent years, with increasing awareness to this disease, the diagnosis and treatment of M-HLH have been renewed constantly. ![]() M-HLH is a life-threatening disease with an interdisciplinary complex of symptoms, high incidence of misdiagnosis and mortality. Malignancy is an important trigger of secondary HLH, and the incidence of malignancy-associated HLH(M-HLH) increases with age. Hemophagocytic lymphohistiocytosis(HLH) is a critical condition characterized by the undue activation of cytotoxic T lymphocytes, natural killer cells, and macrophages, resulting in excessive secretion of infammatory cytokines.
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